l-DOPA modifies the antidepressant-like effects of reboxetine and fluoxetine in rats
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l-DOPA modifies the antidepressant-like effects of reboxetine and fluoxetine in rats
Nowadays the most widely used antidepressants are selective serotonin reuptake inhibitors (SSRI) or noradrenaline reuptake inhibitors (NRI), however, these take four to eight weeks to exert their effects and each drug is efficacious only in 60-70% of patients. In an attempt to improve the efficacy of antidepressants, new drugs that also modify dopamine levels are being developed. The aim of thi...
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متن کاملNoradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test.
The novel antidepressant reboxetine is a selective norepinephrine reuptake inhibitor. In this study, the antidepressant-like effects of reboxetine were characterized in a modified rat forced swim test. Further, in order to investigate the role of the locus coeruleus and lateral tegmental noradrenergic systems in the mediation of reboxetine's effects, the impact of different chemical lesions of ...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2013
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2012.11.016